An osteoclast is a large multinucleated cell and human osteoclasts on bone typically have five nuclei and are 150–200 µm in diameter. When osteoclast-inducing cytokines are used to convert macrophages to osteoclasts, very large cells that may reach 100 µm in diameter occur. These may have dozens of nuclei, and typically express major Function: Breakdown of bone tissue. Osteoblast builds up bone and is found in immature bone but osteocyte is a mature bone cell found in mature bone tissue. Osteoclast cells increase the level of calcium in your blood. There.
May 15, 2003 · Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, Cited by: 6700. Aug 01, 2003 · We analyzed the ability of IL-4 to directly regulate osteoclast differentiation and mature osteoclast function. We found that IL-4 inhibited the differentiation of osteoclasts from bone marrow precursors in an irreversible manner and also inhibited the resorptive capacity of mature osteoclasts.
Because functionally active c-FMS are present on mature osteoclasts (Hofstetter et al., 1992), we speculated that osteoclasts could represent a potential target for imatinib. In this study, using a model of rabbit osteoclasts, which is one of the most appropriate models currently used to obtain authentic mature osteoclasts, we demonstrated that Cited by: 89. process begins with the removal of mature, mineralized bone tissue by osteoclasts. Their degradarive abilities allow osteoblasts to enter and secrete osteoid. Upon the osteoblasts becoming trapped in their own osteoid, new osteocytes are formed.
In conclusion, we have shown that RANK mRNA is expressed in mature rat and human osteoclasts and that sRANKL activates signalling pathways associated with the RANK receptor. Our demonstration of sRANKL induction of nuclear and cytosolic Ca 2+ changes may be relevant in osteoclast activation. Further analysis of sRANKL effects on pure Cited by: 96. Nov 26, 2015 · S. aureus provoked the enhancement of the osteoclast differentiation and the release of pro-inflammatory cytokines (Kim et al., 2013). These cytokines enhanced the bone resorption capacity of uninfected mature osteoclasts and promoted osteoclastogenesis of the uninfected precursors (Trouillet-Assant et al., 2015).Cited by: 66.
1) Osteoclast inhibition- 15 mins. after secretion, calcitonin reduces osteoclast activity by 70%; so osteoclasts liberate less calcium from skeleton. 2) Osteoblast stimulation- 60 mins. after secretion, calcitonin increases the number and activity of osteoblasts, which deposit calcium into the skeleton. May 03, 1999 · Keywords: osteoclast, bone resorption, bone remodeling, osteoporosis, hematopoietic cell growth factors In addition to its role in OC differentiation, we previously reported that OPGL induces a dose-dependent increase in the number of resorption lacunae generated by mature OCs on Cited by: 931.